顧寧

發布者：張寧發布時間：2021-09-10瀏覽次數：139

聯系方式

郵箱：guning@hit.edu.cn

個人簡介

1998-2002年：日本京都教育大學理學學士

2002-2004年：日本京都大學環境學碩士

2004-2007年：日本京都大學環境學博士

2007-2009年：日本學術振興會（JSPS）博士后

2009-2010年：日本產業技術研究所博士后

2010-2015年：哈爾濱工業大學生命學院副教授

2016-現在：哈爾濱工業大學生命學院教授

Personal Profile

1998-2002: Japan Kyoto University of Education Bachelor of Science

2002-2004: Japan Kyoto University Master of Environmental Science

2004-2007: Japan Kyoto University PhD of Environmental Science

2007-2009: Japan Japan Society for the Promotion of Science (JSPS) Postdocs

2009-2010: Japan National Institute of Advanced Industrial Science and Technology Postdocs

2010-2015: Harbin Institute of Technology School of Life Science and Technology Assistant Professor

2016-now: Harbin Institute of Technology School of Life Science and Technology Professor

研究方向和領域

藥理毒理學與內分泌疾病領域的研究

Research Area

pharma-toxicology and endocrine diseases

研究內容

1. 糖尿病、肥胖癥等內分泌疾病相關基因功能的研究

2. 納米粒子、小分子化合物的藥理及毒理研究

3. 環境污染物對健康影響及分子機制研究

Research Interests

1. Functions of genes associated with endocrine diseases such as diabetes and obesity

2. Pharmacological and toxicological effects of nanoparticles and small molecule compounds

3. Effects of environment pollutions on health and its molecular mechanisms

研究成果

1. Daqian Yang, Xiaoting Zhang, Lei Yue, Hailong Hu, Xiangjuan Wei, Qian Guo, Boya Zhang, Xingpei Fan, Yuan Xin, Yuri Oh, Ning Gu*. Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression. Chemosphere, 2021, 273:129727.（代表作）

2. Hailong Hu, Qian Guo, Xingpei Fan, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou, Ning Gu*. Molecular mechanisms underlying zinc oxide nanoparticle induced insulin resistance in mice. Nanotoxicology. 2020 Feb;14(1):59-76. （代表作）

3. Hailong Hu, Xingpei Fan, Qian Guo, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng, Kun Chen, Liping Hou, Ning Gu*. Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species. Particle and Fibre Toxicology. 2019, Vol.16:41.（代表作）

4. Qian Guo，Hailong Hu，Ying Zhoua，Yuheng Yan，Xiangjuan Wei，Xingpei Fan，Daqian Yang，Hongjuan He，Yuri Oh，Kun Chen，Qiong Wu，Chuanpeng Liu，Ning Gu*.Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells. Food Chem Toxicol, 2019 March; 125: 95-105.

5. Hu Hailong, Li Li, Guo Qian, Zong He, Yan Yuheng, Yin Yao, Wang Yu, Oh, Yuri, Feng Yujie, Wu Qiong, Ning Gu*. RNA sequencing analysis shows that titaniumdioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice. Nanotoxicology, 2018 May;12(4):341-356.

6. 顧寧*, 胡海龍, 毛軻, 郭倩. 一種促進肌肉細胞中GLUT4基因表達的方法: ZL2014 10076511.1. 2016-09-07.

7. 顧寧*, 岳磊，胡海龍, 郭倩, 毛軻. SB505124在制備治療軟骨損傷的藥物中的應用: ZL2014 10200906.8. 2016-01-27.

8. 顧寧*, 岳磊, 胡海龍. 一種提高人間充質干細胞分化能力的方法: ZL2014 10264739.3. 2016-08-24.

9. 顧寧*, 馬卓, 胡海龍, 郭倩. 一種檢測臟器組織中是否存在納米顆粒的方法: ZL2014 10465607.7. 2017-01-04.

開設的課程

生物制品

Biologicology

教師個人主頁鏈接

http://homepage.hit.edu.cn/guning